[Rat tissues antioxidant status correction by peptide delta sleep during physiological aging of the organism].

Abstract

It is shown that exogenous delta-sleep inducing peptide increases glutathione antioxidant system level in rat tissues at different stages of ontogenesis, by subcutaneous injection to rats 2-24 months postnatal development in a dose of 100 mg/kg animal body weight by courses of 5 consecutive days per month, and this effect is especially marked in non-renewable postmitotic tissues.

• Authors: T I Bondarenko, D S Kutilin, I I Mikhaleva
• Journal: Advances in gerontology = Uspekhi gerontologii (Adv Gerontol) Vol. 27 Issue 1 Pg. 98-107 ( 2014) ISSN: 1561-9125 [Print] Russia (Federation)
• PMID: 25051765 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Delta Sleep-Inducing Peptide
• Glutathione Peroxidase
• Glutathione Reductase
• Glutathione Transferase
• Glutathione

Topics

• Adaptation, Physiological (physiology)
• Age Factors
• Aging (drug effects, metabolism, pathology)
• Animals
• Antioxidants (physiology)
• Cellular Senescence (drug effects, physiology)
• Delta Sleep-Inducing Peptide (administration & dosage, metabolism)
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Glutathione Reductase
• Glutathione Transferase (metabolism)
• Rats