Pentraxin 3 concentrations of the mothers with preterm premature rupture of membranes and their neonates, and early neonatal outcome.

Abstract

BACKGROUND:

Pentraxin 3 (PTX3) is an acute phase reactant which has been used to detect intra-amniotic infections (IAI) in pregnancy, but the prognostic value of PTX3 concentrations on neonates has not been studied. We aimed to investigate the relationship between maternal PTX3-neonatal PTX3 concentrations and early neonatal outcome.

METHODS:

The mothers diagnosed with preterm prelabor rupture of membranes (PPROM) (n = 28) and their preterm infants (n = 28) were included in the study. PTX3 concentrations were studied in plasma in the maternal peripheral blood and umbilical/peripheral vein in the neonates. The relationship between the mPTX3-nPTX3 concentrations and neonatal outcome were investigated using non-parametric tests and binary logistic regression analysis.

RESULTS:

The mean mPTX3 concentration was 10.35 ± 7.82 μg/L. Ten (35.7%) of all mothers were within the normal range and 18 (64.3%) in high percentile (≥ 97.5 percentile). There was no relation between mPTX3 concentrations and clinical or histologic chorioamnionitis, latency of PPROM, and early neonatal outcome. Mean nPTX3 concentrations was 9.18 ± 7.83 μg/L and high nPTX3 concentrations were detected in five (17.8%) neonates. nPTX3 concentrations were inversely correlated with gestational age and correlated with rate of intraventricular hemorrhage (IVH) and mortality. Neonates with high nPTX3 concentrations also have lowered APGAR scores, increased rate of respiratory distress syndrome, clinical sepsis, IVH, necrotizing enterocolitis and prolonged NICU stay.

CONCLUSION:

High PTX3 concentrations of the newborns are associated with some worsened early neonatal outcome including lower gestational age at delivery, increased rate of IVH and mortality. Maternal PTX3 concentrations are not an adequate marker in defining clinical or histologic chorioamnionitis and early neonatal outcome.

• Authors: Mustafa Ali Akin, Tamer Gunes, Dilek Coban, Mahmut Tuncay Ozgun, Hulya Akgun, Selim Kurtoglu
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 28 Issue 10 Pg. 1170-5 (Jul 2015) ISSN: 1476-4954 [Electronic] England
• PMID: 25048752 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Serum Amyloid P-Component
• PTX3 protein
• C-Reactive Protein

Topics

• Adult
• Apgar Score
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Female
• Fetal Membranes, Premature Rupture (blood)
• Humans
• Infant, Newborn
• Infant, Premature
• Mothers
• Pregnancy
• Pregnancy Outcome
• Serum Amyloid P-Component (metabolism)