Significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high homocysteine level with recurrent aphthous stomatitis.

Abstract

BACKGROUND:

A portion of patients with recurrent aphthous stomatitis (RAS) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin, iron, vitamin B12, and folic acid and high blood homocysteine level with RAS.

METHODS:

The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 273 RAS patients were measured and compared with the corresponding levels in 273 age- and sex-matched healthy control subjects.

RESULTS:

We found that 57 (20.9%), 55 (20.1%), 13 (4.8%), and 7 (2.6%) RAS patients had deficiencies of hemoglobin (Men < 13 g/dl, Women < 12 g/dl), iron (<60 μg/dl), vitamin B12 (<200 pg/ml), and folic acid (<4 ng/ml), respectively. Moreover, 21 (7.7%) RAS patients had abnormally high blood homocysteine level. RAS patients had a significantly higher frequency of hemoglobin, iron, vitamin B12, or folic acid deficiency and of abnormally elevated blood homocysteine level than healthy control subjects (all P-values = 0.000 except for folic acid P = 0.022). If 273 RAS patients were further divided into 32 patients with major-typed RAS (MjRAS) and 241 patients with minor-typed RAS (MiRAS), we found that male MjRAS patients had a significantly lower mean hemoglobin concentration than MiRAS patients (P = 0.021), but MjRAS patients had a significantly higher mean homocysteine level than MiRAS patients (P = 0.000).

CONCLUSION:

We conclude that there is a significant association of deficiencies of hemoglobin, iron, vitamin B12, and folic acid and abnormally high blood homocysteine level with RAS.

• Authors: Andy Sun, Hsin-Ming Chen, Shih-Jung Cheng, Yi-Ping Wang, Julia Yu-Fong Chang, Yang-Che Wu, Chun-Pin Chiang
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 44 Issue 4 Pg. 300-5 (Apr 2015) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 25048341 (Publication Type: Journal Article)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Hemoglobins
• Homocysteine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anemia, Iron-Deficiency (blood)
• Chi-Square Distribution
• Female
• Folic Acid Deficiency (blood)
• Hemoglobins (deficiency)
• Homocysteine (blood)
• Humans
• Male
• Middle Aged
• Stomatitis, Aphthous (blood)
• Vitamin B 12 Deficiency (blood)
• Young Adult