Methotrexate pharmacotherapy for implant-related temporomandibular joint pain: a case report.

Abstract

This article presents a patient experiencing several years of pain associated with bilateral failed temporomandibular joint (TMJ) Proplast/Teflon fossa prostheses. Despite surgical removal of the prostheses and comprehensive conservative management, including typical pharmacotherapy approaches for chronic pain, pain was still not relieved, and management was revised to target a putative chronic inflammatory disorder. Methotrexate was prescribed because of its known efficacy for inflammation and pain reduction in rheumatoid arthritis. Titration of methotrexate dosage over 5 months to a weekly dose of 20 mg resulted in reduced pain intensity at rest, increased pain-free maximal jaw opening, and a reduction in the sensory component of the McGill Pain Questionnaire. Maximum assisted jaw opening remained the same, as did the palpation tenderness of both TMJs and of the masseter and temporalis muscles. Methotrexate pharmacotherapy may represent a viable option when conservative treatments have failed to provide significant pain relief in patients who have had Proplast/Teflon TMJ implants.

• Authors: J Paul Edwards, Erik J Peterson, Justin Durham, Donald R Nixdorf
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 118 Issue 2 Pg. e44-7 (Aug 2014) ISSN: 2212-4411 [Electronic] United States
• PMID: 25047933 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Antirheumatic Agents
• Methotrexate

Topics

• Administration, Oral
• Antirheumatic Agents (therapeutic use)
• Female
• Humans
• Joint Prosthesis (adverse effects)
• Methotrexate (therapeutic use)
• Middle Aged
• Pain Management
• Pain Measurement
• Temporomandibular Joint Disorders (drug therapy, etiology, surgery)