Abstract | BACKGROUND AND OBJECTIVES: METHODS: Nude mice bearing human leukemia xenograft and C57BL/6 mice bearing EL-4 thymic lymphoma were used to evaluate photodynamic efficacy of ZnPcS2P2. The EL-4 thymic lymphoma was used to test the improving anti- tumor efficacy of ZnPcS2P2-PDT in combination with GM-CSF gene-transduced vaccine and B7.1 gene-transduced vaccine. Each vaccine was administered near the tumor bed three times: 2 days before PDT, 0 and 2 days after PDT. RESULTS: ZnPcS2P2-PDT could significantly reduce tumor growth and prolong the survival time in both tumor models. Improving anti- tumor efficacy of ZnPcS2P2-PDT was demonstrated when utilizing GM-CSF-transduced vaccine and B7.1-transduced vaccine prior to and after ZnPcS2P2-PDT in lymphoma-bearing mice. Twenty-five percent of lymphoma-bearing mice were completely cured with a combination of PDT and vaccine cells. CONCLUSIONS: ZnPcS2P2-PDT may be a beneficial treatment for hemotopoietic malignance. GM-CSF-transduced vaccine and B7.1-transduced vaccine could strengthen ZnPcS2P2-PDT-elicited anti- lymphoma potency.
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Authors | Hui-Fang Huang, Yuan-Zhong Chen, Yong Wu, Nai-Nong Li, Ping Chen |
Journal | Photodiagnosis and photodynamic therapy
(Photodiagnosis Photodyn Ther)
Vol. 4
Issue 2
Pg. 100-5
(Jun 2007)
ISSN: 1572-1000 [Print] Netherlands |
PMID | 25047342
(Publication Type: Journal Article)
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