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The effect of pessaries on the vaginal microenvironment.

AbstractOBJECTIVE:
The objective of the study was to evaluate the differences in vaginal culture, microscopy, and Gram stain between postmenopausal women who wear pessaries and those who do not to explain pessary-related, bothersome vaginal discharge.
STUDY DESIGN:
Postmenopausal women not using exogenous estrogen who had either been wearing a pessary for at least 3 months or who were undergoing their first pessary fittings were approached for enrollment. Symptoms were assessed, and vaginal fluid was collected for culture, microscopy, and Gram stain. A cross-sectional analysis was performed, comparing the new and return pessary wearers. The new pessary users were also sampled at 2 weeks, 3 months, and 6 months after fitting.
RESULTS:
Women who wore pessaries were more likely to be bothered by discharge (30.0% vs 2.1%, P < .001). They were also more likely to show microscopic evidence of vaginal inflammation and vaginitis. Prospective data showed that these changes developed during the first 2 weeks of pessary use. Aerobic and anaerobic organisms were nearly identical in women with and without bothersome vaginal discharge in the cross-sectional analysis and at all time points in the prospective analysis.
CONCLUSION:
Pessary-related, bothersome vaginal discharge develops early and may be due to an inflammatory process in the vagina.
AuthorsSarah Collins, Richard Beigi, Colleen Mellen, David O'Sullivan, Paul Tulikangas
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 212 Issue 1 Pg. 60.e1-6 (Jan 2015) ISSN: 1097-6868 [Electronic] United States
PMID25046810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Topics
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Humans
  • Pessaries (adverse effects)
  • Prospective Studies
  • Vagina (microbiology)
  • Vaginal Discharge (microbiology)

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