Abstract | OBJECTIVE: To estimate influenza vaccine coverage and effectiveness against medically attended laboratory-confirmed influenza for the 2012 season. DESIGN, SETTING AND PARTICIPANTS: Test-negative design involving patients recruited as part of the Australian Sentinel Practices Research Network, a network of sentinel general practitioners throughout Australia. Throughout 2012, at the discretion of the GP at one of 102 participating practices, patients presenting with influenza-like illness were swabbed and included in the study. MAIN OUTCOME MEASURE:
Influenza vaccine effectiveness (VE) estimated as (1-OR)*100% by logistic regression. RESULTS: 1775 patients were swabbed. The epidemic period was identified as Weeks 10 to 43 of 2012. After exclusions, there were 1414 patients for the VE analysis, including 593 (42%) who tested influenza-positive and 821 who tested negative. 27% of test-negative patients were vaccinated, of whom most were aged 50 years and over. The overall VE, adjusted for age group, month of presentation and state or territory, was 23% (95% CI, -4% to 43%) against all influenza types, 15% (95% CI, -17% to 38%) against influenza A, 13% (95% CI, -20% to 36%) against influenza A(not H1) and 53% (95% CI, 5% to 77%) against influenza B. CONCLUSION: Vaccination against influenza was modestly protective, reducing the risk of medical presentation with influenza by around 23%.
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Authors | Sheena G Sullivan, Monique B-N Chilver, Geoff Higgins, Allen C Cheng, Nigel P Stocks |
Journal | The Medical journal of Australia
(Med J Aust)
Vol. 201
Issue 2
Pg. 109-11
(Jul 21 2014)
ISSN: 1326-5377 [Electronic] Australia |
PMID | 25045991
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Australia
(epidemiology)
- Child
- Child, Preschool
- Female
- General Practice
- Humans
- Infant
- Influenza Vaccines
- Influenza, Human
(diagnosis, epidemiology, prevention & control)
- Logistic Models
- Male
- Middle Aged
- Sentinel Surveillance
- Vaccination
(statistics & numerical data)
- Young Adult
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