Cationic oligo(p-phenylene vinylene) materials for combating drug resistance of cancer cells by light manipulation.

Abstract

An unconventional strategy that can be temporally and remotely activated with light to combat the drug resistance of cancer cells is developed. A cell-membrane-anchored photosensitizer (OPV) is used to enhance anticancer drug uptake and restore toxicity in resistant cancer cells. This method recovers the activity of the already established anticancer drugs, and provides a new strategy for the development of light manipulation to combat anticancer resistance.

• Authors: Bing Wang, Huanxiang Yuan, Zhang Liu, Chenyao Nie, Libing Liu, Fengting Lv, Yilin Wang, Shu Wang
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 26 Issue 34 Pg. 5986-90 (Sep 10 2014) ISSN: 1521-4095 [Electronic] Germany
• PMID: 25044102 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Cations
• Photosensitizing Agents
• Polyvinyls
• oligo(p-phenylene vinylene)
• Doxorubicin

Topics

• Antineoplastic Agents (chemistry, pharmacokinetics, pharmacology)
• Cations (chemistry)
• Cell Membrane Permeability
• Cell Survival (drug effects, radiation effects)
• Dose-Response Relationship, Drug
• Doxorubicin (chemistry, pharmacokinetics, pharmacology)
• Drug Resistance, Neoplasm (drug effects, radiation effects)
• Humans
• Light
• MCF-7 Cells
• Microscopy, Confocal
• Photochemotherapy (methods)
• Photosensitizing Agents (pharmacology)
• Polyvinyls (chemistry, pharmacokinetics, pharmacology)