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Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone.

AbstractOBJECTIVE:
To determine the effect of enclomiphene citrate in men with secondary hypogonadism.
DESIGN:
Phase II clinical trial.
SETTING:
Community dwelling men making visits to physician offices.
PATIENT(S):
Men with secondary hypogonadism.
INTERVENTION(S):
Oral administration of enclomiphene citrate or 1% topical T gel.
MAIN OUTCOME MEASURE(S):
Luteinizing hormone, FSH, T, and semen analysis.
RESULT(S):
Treatment with enclomiphene citrate resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in men with secondary hypogonadism. Follicle-stimulating hormone and LH were increased with enclomiphene, and sperm counts were conserved.
CONCLUSION(S):
Enclomiphene citrate reverses the two hallmarks of secondary hypogonadism, namely, low serum total T and low or inappropriately normal LH while preserving sperm production.
CLINICAL TRIAL REGISTRATION NUMBER:
NCT01270841 (ClinicalTrials.gov Identifier NCT01270841).
AuthorsRonald D Wiehle, Gregory K Fontenot, Jenny Wike, Kuang Hsu, Jennifer Nydell, Larry Lipshultz, ZA-203 Clinical Study Group
JournalFertility and sterility (Fertil Steril) Vol. 102 Issue 3 Pg. 720-7 (Sep 2014) ISSN: 1556-5653 [Electronic] United States
PMID25044085 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial)
CopyrightCopyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Sex Hormone-Binding Globulin
  • Testosterone
  • Estradiol
  • boldenone
  • Luteinizing Hormone
  • Enclomiphene
Topics
  • Administration, Oral
  • Administration, Topical
  • Adult
  • Enclomiphene (therapeutic use)
  • Estradiol (blood)
  • Humans
  • Hypogonadism (drug therapy)
  • Luteinizing Hormone (blood)
  • Male
  • Middle Aged
  • Oligospermia (blood, prevention & control)
  • Sex Hormone-Binding Globulin (analysis)
  • Testosterone (administration & dosage, analogs & derivatives, blood)
  • Up-Regulation (drug effects)

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