Effects of combined therapy with glipizide and Aralia root bark extract on glycemic control and lipid profiles in patients with type 2 diabetes mellitus.

Abstract

BACKGROUND:

The root bark of Aralia is a rich source of bioactive components that may improve glycemic control and lipid status. In this study, 148 patients with type 2 diabetes mellitus (T2DM) were assigned randomly to receive either glipizide alone or glipizide plus Aralia root bark extract (ARBE) for 8 weeks to test the effects of ARBE plus glipizide therapy on glycemic control and lipid profiles in these patients.

RESULTS:

Levels of HbA1c, fasting plasma glucose (FPG) and 2 h postprandial plasma glucose (2-h PPG) in both groups significantly decreased from baseline. Glycated hemoglobin (HbA1c) decreased marginally significantly in participants taking glipizide plus ARBE compared with the glipizide group (P = 0.06). Participants in the combination group had significant decreases in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), and the between-group difference achieved statistical significance for LDL-C (P = 0.04). Reduction in HbA1c in the combination group was significantly associated with changes in TC (r = 0.32; P = 0.006) and LDL-C (r = 0.34; P = 0.005), and the change in FPG was inversely correlated with LDL-C reduction (r = 0.34; P = 0.004).

CONCLUSIONS:

In patients with T2DM, combination therapy with glipizide and ARBE resulted in moderately lowering HbA1c and LDL-C levels compared with glipizide alone.

• Authors: Xiao-Hong Liu, Xing-Min Li, Cheng-Cheng Han, Xiang-Feng Fang, Le Ma
• Journal: Journal of the science of food and agriculture (J Sci Food Agric) Vol. 95 Issue 4 Pg. 739-44 (Mar 15 2015) ISSN: 1097-0010 [Electronic] England
• PMID: 25042995 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 Society of Chemical Industry.

Chemical References

• Antioxidants
• Hypoglycemic Agents
• Hypolipidemic Agents
• Plant Extracts
• Glipizide

Topics

• Antioxidants (adverse effects, therapeutic use)
• Aralia (chemistry)
• China
• Combined Modality Therapy (adverse effects)
• Diabetes Mellitus, Type 2 (blood, complications, diet therapy, drug therapy)
• Dietary Supplements (adverse effects)
• Double-Blind Method
• Female
• Glipizide (therapeutic use)
• Humans
• Hyperglycemia (prevention & control)
• Hyperlipidemias (complications, prevention & control)
• Hypoglycemic Agents (therapeutic use)
• Hypolipidemic Agents (adverse effects, therapeutic use)
• Intention to Treat Analysis
• Lost to Follow-Up
• Male
• Middle Aged
• Patient Dropouts
• Plant Bark (chemistry)
• Plant Extracts (adverse effects, therapeutic use)