Clinical experience with long-term acetazolamide treatment in children with nondystrophic myotonias: a three-case report.

Abstract

BACKGROUND:

Today, treatment of the nondystrophic myotonias consists of mexiletine, although care has to be taken because of the proarrhythmogenic potential of this drug. In this article, we report years of experience with the carbonic anhydrase inhibitor acetazolamide.

PATIENTS:

We present three children with nondystrophic myotonias.

RESULTS:

During acetazolamide treatment, symptoms and signs of myotonia decreased in our children.

CONCLUSIONS:

Based on this clinical experience and the favorable pharmacologic profile of acetazolamide, it may be a good treatment option for children with nondystrophic myotonias.

• Authors: Joekie M Markhorst, Bas C Stunnenberg, Ieke B Ginjaar, Gea Drost, Corrie E Erasmus, Lilian T L Sie
• Journal: Pediatric neurology (Pediatr Neurol) Vol. 51 Issue 4 Pg. 537-41 (Oct 2014) ISSN: 1873-5150 [Electronic] United States
• PMID: 25042881 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Carbonic Anhydrase Inhibitors
• Acetazolamide

Topics

• Acetazolamide (administration & dosage, pharmacology)
• Adolescent
• Carbonic Anhydrase Inhibitors (administration & dosage, pharmacology)
• Child
• Female
• Humans
• Male
• Myotonia (diagnosis, drug therapy)
• Treatment Outcome