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In utero resolution of microcystic congenital cystic adenomatoid malformation after prenatal betamethasone therapy: A report of three cases and a literature review.

Abstract
Fetal congenital cystic adenomatoid malformation (CCAM) can progress to nonimmune hydrops, and the mortality rate of CCAM with hydrops is reported to be nearly 100%. We describe three microcystic CCAM cases in which the fetal condition improved after maternal betamethasone therapy. The median gestational age at steroid administration was 23 5/7 weeks' gestation. The CCAM decreased in size in all cases. Our series showed a 100% hydrops resolution rate (2/2) and a 100% survival rate (3/3). Our experience suggests the efficacy of betamethasone treatment on fetuses with microcystic CCAM who have fluid collection or are at risk of developing hydrops.
AuthorsAkiko Yamashita, Nobuhiro Hidaka, Ryo Yamamoto, Soichiro Nakayama, Jun Sasahara, Keisuke Ishii, Nobuaki Mitsuda
JournalJournal of clinical ultrasound : JCU (J Clin Ultrasound) Vol. 43 Issue 7 Pg. 451-7 (Sep 2015) ISSN: 1097-0096 [Electronic] United States
PMID25042751 (Publication Type: Case Reports, Journal Article, Review)
Copyright© 2014 Wiley Periodicals, Inc.
Chemical References
  • Glucocorticoids
  • Betamethasone
Topics
  • Adult
  • Betamethasone (therapeutic use)
  • Cystic Adenomatoid Malformation of Lung, Congenital (diagnostic imaging, drug therapy)
  • Female
  • Fetal Diseases (diagnostic imaging, drug therapy)
  • Glucocorticoids (therapeutic use)
  • Humans
  • Pregnancy
  • Treatment Outcome
  • Ultrasonography, Prenatal

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