Light-stable bis(norharmane)silver(I) compounds: synthesis, characterization and antiproliferative effects in cancer cells.

Abstract

Four different-anion Ag(I) compounds with the ligand norharmane (9H-Pyrido[3,4-b]indole; Hnor) and having the general formula [Ag(Hnor)2](anion) (anion=ClO4(-), NO3(-) and BF4(-)) [Ag(Hnor)2(MeCN)](PF6) are reported, and studied in detail regarding their coordination mode and in vitro antiproliferative effects. X-ray structural analysis revealed that the complex with the PF6(-) anion has a MeCN solvent molecule weakly coordinated to Ag(I), making the metal coordination T-shaped, while the other compounds present the classical linear Ag(I) coordination. The compounds showed certain cell growth inhibitory effects in two different cancer cell lines, with the perchlorate containing complex being the most toxic and in fact comparable to cisplatin. Notably, the compounds are stable in visible light; and the luminescence in the solid state was found to be extremely weak, whereas in MeOH solution all compounds show a moderate to weak emission band at 375 nm, when excited at 290 nm.

• Authors: Rais Ahmad Khan, Khalid Al-Farhan, Andreia de Almeida, Ali Alsalme, Angela Casini, Mohamed Ghazzali, Jan Reedijk
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 140 Pg. 1-5 (Nov 2014) ISSN: 1873-3344 [Electronic] United States
• PMID: 25042730 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Carbolines
• Silver
• Harmine
• norharman

Topics

• Carbolines
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Harmine (analogs & derivatives, chemical synthesis, chemistry, pharmacology)
• Humans
• Light
• Lung Neoplasms (pathology)
• Proton Magnetic Resonance Spectroscopy
• Silver (chemistry)
• X-Ray Diffraction