Abstract | OBJECTIVE: To study cerebrospinal fluid and protein indices characterizing the permeability of the hematoencephalitic barrier and intrathecal immunoglobulin synthesis in children with different course and outcome of demyelinating diseases of the central nervous system. MATERIAL AND METHODS: We examined 72 children with demyelinating diseases of the central nervous system and 16 children of a control group (without neuroinfections). RESULTS: CONCLUSION: The alterations in the indices obtained in this study can be included in the algorithm of laboratory examination. The results prove the involvement of various mechanisms in the pathogenesis of demyelinating diseases of the central nervous system in children.
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Authors | L A Alekseeva, N V Skripchenko, T V Bessonova, G P Ivanova, N E Monakhova |
Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
(Zh Nevrol Psikhiatr Im S S Korsakova)
Vol. 114
Issue 6
Pg. 48-52
( 2014)
ISSN: 1997-7298 [Print] Russia (Federation) |
PMID | 25042491
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Immunoglobulin G
- Myelin Basic Protein
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Topics |
- Adolescent
- Blood-Brain Barrier
(physiopathology)
- Child
- Child, Preschool
- Encephalomyelitis, Acute Disseminated
(cerebrospinal fluid, physiopathology)
- Humans
- Immunoglobulin G
(cerebrospinal fluid)
- Infant
- Male
- Multiple Sclerosis
(cerebrospinal fluid)
- Myelin Basic Protein
(cerebrospinal fluid)
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