Abstract |
Factors released by glioma-associated microglia/macrophages ( GAMs) play an important role in the growth and infiltration of tumors. We have previously demonstrated that the co-chaperone stress-inducible protein 1 (STI1) secreted by microglia promotes proliferation and migration of human glioblastoma (GBM) cell lines in vitro. In the present study, in order to investigate the role of STI1 in a physiological context, we used a glioma model to evaluate STI1 expression in vivo. Here, we demonstrate that STI1 expression in both the tumor and in the infiltrating GAMs and lymphocytes significantly increased with tumor progression. Interestingly, high expression of STI1 was observed in macrophages and lymphocytes that infiltrated brain tumors, whereas STI1 expression in the circulating blood monocytes and lymphocytes remained unchanged. Our results correlate, for the first time, the expression of STI1 and glioma progression, and suggest that STI1 expression in GAMs and infiltrating lymphocytes is modulated by the brain tumor microenvironment.
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Authors | Anna Carolina Carvalho da Fonseca, Huaqing Wang, Haitao Fan, Xuebo Chen, Ian Zhang, Leying Zhang, Flavia Regina Souza Lima, Behnam Badie |
Journal | Journal of neuroimmunology
(J Neuroimmunol)
Vol. 274
Issue 1-2
Pg. 71-7
(Sep 15 2014)
ISSN: 1872-8421 [Electronic] Netherlands |
PMID | 25042352
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2014 Elsevier B.V. All rights reserved. |
Chemical References |
- CX3C Chemokine Receptor 1
- Cx3cr1 protein, mouse
- Heat-Shock Proteins
- Receptors, Chemokine
- Stip1 protein, mouse
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Topics |
- Animals
- Brain Neoplasms
(immunology, metabolism)
- CX3C Chemokine Receptor 1
- Cell Line, Tumor
- Disease Progression
- Female
- Flow Cytometry
- Gene Expression
(immunology)
- Glioma
(immunology, metabolism)
- Heat-Shock Proteins
(genetics, immunology, metabolism)
- Lymphocytes
(immunology)
- Macrophages
(immunology)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microglia
(immunology)
- Receptors, Chemokine
(genetics)
- Tumor Microenvironment
(immunology)
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