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Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.

Abstract
Factors released by glioma-associated microglia/macrophages (GAMs) play an important role in the growth and infiltration of tumors. We have previously demonstrated that the co-chaperone stress-inducible protein 1 (STI1) secreted by microglia promotes proliferation and migration of human glioblastoma (GBM) cell lines in vitro. In the present study, in order to investigate the role of STI1 in a physiological context, we used a glioma model to evaluate STI1 expression in vivo. Here, we demonstrate that STI1 expression in both the tumor and in the infiltrating GAMs and lymphocytes significantly increased with tumor progression. Interestingly, high expression of STI1 was observed in macrophages and lymphocytes that infiltrated brain tumors, whereas STI1 expression in the circulating blood monocytes and lymphocytes remained unchanged. Our results correlate, for the first time, the expression of STI1 and glioma progression, and suggest that STI1 expression in GAMs and infiltrating lymphocytes is modulated by the brain tumor microenvironment.
AuthorsAnna Carolina Carvalho da Fonseca, Huaqing Wang, Haitao Fan, Xuebo Chen, Ian Zhang, Leying Zhang, Flavia Regina Souza Lima, Behnam Badie
JournalJournal of neuroimmunology (J Neuroimmunol) Vol. 274 Issue 1-2 Pg. 71-7 (Sep 15 2014) ISSN: 1872-8421 [Electronic] Netherlands
PMID25042352 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
CopyrightCopyright © 2014 Elsevier B.V. All rights reserved.
Chemical References
  • CX3C Chemokine Receptor 1
  • Cx3cr1 protein, mouse
  • Heat-Shock Proteins
  • Receptors, Chemokine
  • Stip1 protein, mouse
Topics
  • Animals
  • Brain Neoplasms (immunology, metabolism)
  • CX3C Chemokine Receptor 1
  • Cell Line, Tumor
  • Disease Progression
  • Female
  • Flow Cytometry
  • Gene Expression (immunology)
  • Glioma (immunology, metabolism)
  • Heat-Shock Proteins (genetics, immunology, metabolism)
  • Lymphocytes (immunology)
  • Macrophages (immunology)
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microglia (immunology)
  • Receptors, Chemokine (genetics)
  • Tumor Microenvironment (immunology)

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