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Mosapride treatment for functional dyspepsia: a meta-analysis.

AbstractBACKGROUND AND AIM:
The aim of this study was to assess the therapeutic effect of mosapride in patients with functional dyspepsia (FD).
METHODS:
Randomized controlled trials (RCTs) of mosapride for the treatment of FD performed between 2002 and 2013 were identified from databases. Symptom response rates were extracted and analyzed using risk ratios (RRs). A random effect model was applied based on Higgins I(2) tests. Publication bias was evaluated using a funnel plot, Egger's test, trim and fill, and the rank correlation test.
RESULTS:
In total, 13 RCTs, which included 1091 mosapride-treated patients and 1129 control patients (on placebo or other drugs), were identified and analyzed. Overall, mosapride showed an RR of 0.999 (95% confidence interval [CI]: 0.869-1.150, P = 0.992) for improving global efficacy or symptom-based scores. In a sensitivity analysis of the high-quality RCTs, mosapride showed an RR of 1.114 (95% CI: 1.011-1.227, P = 0.029). However, in the studies using the Rome III criteria for the diagnosis of FD, mosapride showed an RR of 0.906 (95% CI: 0.807-1.016, P = 0.092). In the studies having funding source, mosapride showed an RR of 1.131 (95% CI: 1.028-1.244, P = 0.012), whereas an RR of 0.966 (95% CI: 0.896-1.042, P = 0.367) was observed in the studies without funding source. Publication bias was not detected.
CONCLUSION:
In this analysis, we could not find a significant effect of mosapride on FD. Inconsistent diagnostic criteria for FD and different assessment outcomes are causes of heterogeneity. Further studies using common validated outcomes or questionnaires and high-quality RCTs will elucidate the real effect of this medication on FD.
AuthorsChang Seok Bang, Jong Hyeok Kim, Gwang Ho Baik, Hyo Sun Kim, Sang Hyun Park, Eun Jin Kim, Jin Bong Kim, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim
JournalJournal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 30 Issue 1 Pg. 28-42 (Jan 2015) ISSN: 1440-1746 [Electronic] Australia
PMID25041564 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Copyright© 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.
Chemical References
  • Benzamides
  • Gastrointestinal Agents
  • Morpholines
  • Serotonin Receptor Agonists
  • mosapride
Topics
  • Benzamides (therapeutic use)
  • Databases, Bibliographic
  • Dyspepsia (drug therapy)
  • Gastrointestinal Agents (therapeutic use)
  • Humans
  • Morpholines (therapeutic use)
  • Randomized Controlled Trials as Topic
  • Serotonin Receptor Agonists (therapeutic use)
  • Treatment Outcome

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