The relationship of Prohepcidin levels with anemia and inflammatory markers in non-diabetic uremic patients: a controlled study.
Abstract | INTRODUCTION: METHODS: RESULTS: Serum Prohepcidin levels in the predialysis, HD, PD and the control groups were 119.6 ± 45.1 ng/mL, 140.2 ± 41.8 ng/mL, 148.2 ± 35.0 ng/mL and 93.8 ± 21.9 ng/mL, respectively (p < 0.001). Prohepcidin was positively correlated with urea (r = 0.345, p = 0.002), creatinine (r = 0.465, p < 0.001), phosphorus (r = 0.253, p = 0.025), hsCRP (r = 0.275, p = 0.019), duration of dialysis treatment (r = 0.443, p < 0.001), fibrinogen (r = 0.467, p < 0.001) and IL-6 (r = 0.615, p < 0.001) levels. A negative correlation was detected between Prohepcidin levels and albumin (r = -0.286, p < 0.001), TIBC (r = -0.573, p < 0.001), GFR (r = -0.473, p < 0.001), hemoglobin (r = -0.351, p = 0.002) and hematocrit (r = -0.342, p = 0.002) levels. DISCUSSION:
Prohepcidin levels increase with deepening anemia and show positive correlation with inflammatory markers. Therapeutic interventions regarding Prohepcidin action on inflammatory status may play a role in the treatment of anemia due to inflammation. Functional iron deficiency is frequent in uremic patients. It may be beneficial to measure Prohepcidin level together with ferritin among these patients.
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Authors | Zeki Aydin, Meltem Gursu, Serhat Karadag, Sami Uzun, Abdullah Sumnu, Yasemin Doventas, Savas Ozturk, Rumeyza Kazancioglu |
Journal | Renal failure
(Ren Fail)
Vol. 36
Issue 8
Pg. 1253-7
(Sep 2014)
ISSN: 1525-6049 [Electronic] England |
PMID | 25040737
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Hepcidins
- Iron
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Topics |
- Anemia
(blood, complications)
- Biomarkers
(blood)
- Case-Control Studies
- Cross-Sectional Studies
- Diabetes Mellitus
- Female
- Hepcidins
(blood)
- Humans
- Inflammation
(blood, complications)
- Iron
(blood)
- Male
- Middle Aged
- Renal Dialysis
- Renal Insufficiency, Chronic
(blood, complications, therapy)
- Uremia
(blood, complications)
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