Long-term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6-month randomized, vehicle-controlled clinical trial.

Abstract

OBJECTIVE:

To evaluate the effectiveness of 0.07% cetylpyridinium chloride (CPC) mouth rinse for reduction of gingival inflammation and inhibition of plaque compared to a vehicle control (VC) mouth rinse over a 6-month period.

MATERIALS & METHODS:

Participants (n = 62) used their randomly assigned product as adjunct to toothbrushing. Bleeding, plaque and staining scores were assessed at baseline, 3 and 6 months. Plaque and saliva samples were taken at each assessment monitoring possible shifts in the composition of the microbiota.

RESULTS:

A significant difference (P = 0.002) in favour of the CPC mouth rinse, with respect to plaque scores, was found. Bleeding scores at 6 months were not significantly different (P = 0.089). However, when correcting for baseline values, a tendency towards a significant difference in bleeding scores at end trail was observed in favour of the CPC mouth rinse (P = 0.061). Regarding staining at 3 and 6 months, a small but significant difference (8.6% and 10.4%, respectively) (P < 0.0001) was observed with lower scores for the VC group. There was a significant reduction in total anaerobic count in the CPC group at 6 months (P < 0.05). The ratio of aerobes/anaerobes was markedly increased at 3 months, especially in the CPC group. No further differences were observed between groups at 6 months.

CONCLUSIONS:

The use of 0.07% CPC mouth rinse was significantly more effective in reducing plaque scores than the vehicle control. Bleeding scores were not different at 6 months. The test product was well accepted and did not cause any serious clinical side effects or negatively affected the microbiota.

• Authors: M P C Van Leeuwen, N A M Rosema, P A Versteeg, D E Slot, A J Van Winkelhoff, G A Van der Weijden
• Journal: International journal of dental hygiene (Int J Dent Hyg) Vol. 13 Issue 2 Pg. 93-103 (May 2015) ISSN: 1601-5037 [Electronic] England
• PMID: 25040299 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Anti-Infective Agents, Local
• Mouthwashes
• Pharmaceutical Vehicles
• Placebos
• Cetylpyridinium

Topics

• Adolescent
• Adult
• Anti-Infective Agents, Local (therapeutic use)
• Bacteria, Aerobic (drug effects)
• Bacteria, Anaerobic (drug effects)
• Bacterial Load (drug effects)
• Cetylpyridinium (therapeutic use)
• Dental Plaque (microbiology, prevention & control)
• Double-Blind Method
• Female
• Follow-Up Studies
• Gingival Hemorrhage (prevention & control)
• Gingivitis (prevention & control)
• Humans
• Lactobacillus (drug effects)
• Longitudinal Studies
• Male
• Mouthwashes (therapeutic use)
• Pharmaceutical Vehicles
• Placebos
• Saliva (microbiology)
• Streptococcus (drug effects)
• Tooth Discoloration (chemically induced)
• Toothbrushing (methods)
• Treatment Outcome
• Young Adult