[Research on volatile components of gualou guizhi decoction and its components in rat brain by GC-MS].

Abstract

To investigate the role of volatile components in the compound and to find the substance foundation of Gualou Guizhi decoction (GLGZD) for curing extremities spasticity after stroke. The chemical compositions of essential oil, obtained by hydrodistillation from Gualou Guizhi decoction and its major constituting herbs (Trichosanthis Radix, Paeoniae Alba Radix, Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Glycyrrhizae Radix, Ziziphi Jujubae Fructus) were analyzed by GC-MS to evaluate the correlativity between volatile components of GLGZD and its major constituting herbs, and volatile components after oral administration of GLGZD in the rats' brain. Volatile components of GLGZD are mainly derived from Cinnamomi Ramulus, Zingiberis Recens Rhizoma, Ziziphi Jujubae Fructus, Trichosanthis Radix. The volatile components in the brain is mostly derived from radix trichosanthis. Compared with individual herbs of GLGZD, the dissolution of the components increase or new components appear after compatibility of six herbs. Adminstrated with GLGZD, the results point out that volatile components in the brain play a neuroprotective role through passing the brain.

• Authors: Huang Li, Wen Xu, Wei Xu, Yu-Qin Zhang, Ke-Dan Chu, Li-Dian Chen, Xian-Wen Chen
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 39 Issue 8 Pg. 1509-15 (Apr 2014) ISSN: 1001-5302 [Print] China
• PMID: 25039192 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Volatile Organic Compounds

Topics

• Animals
• Brain (drug effects)
• Drugs, Chinese Herbal (chemistry, pharmacology)
• Gas Chromatography-Mass Spectrometry
• Male
• Rats
• Rats, Sprague-Dawley
• Volatile Organic Compounds (chemistry, pharmacology)