Abstract | BACKGROUND: METHODS: In a single-blind, randomized controlled trial, 43 patients with PSD were randomly assigned to 12 sessions of DCEAS plus SSRI plus body electroacupuncture (n = 23), or sham (non-invasive cranial electroacupuncture, n-CEA) plus SSRI plus body electroacupuncture (n = 20) for 3 sessions per week over 4 weeks. Treatment outcomes were measured using the 17-item Hamilton Depression Rating Scale (HAMD-17), the Clinical Global Impression - Severity scale (CGI-S) and Barthel Index (BI), a measure used to evaluate movement ability associated with daily self-caring activity. RESULTS: DCEAS produced a significantly greater reduction of both HAMD-17 and CGI-S as early as week 1 and CGI-S at endpoint compared to n-CEA, but subjects of n-CEA group exhibited a significantly greater improvement on BI at week 4 than DCEAS. Incidence of adverse events was not different in the two groups. CONCLUSIONS: These results indicate that DCEAS could be effective in reducing stroke patients' depressive symptoms. Superficial electrical stimulation in n-CEA group may be beneficial in improving movement disability of stroke patients. A combination of DCEAS and body acupuncture can be considered a treatment option for neuropsychiatric sequelae of stroke. TRIAL REGISTRATION: http://www.clinicaltrials.gov, NCT01174394.
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Authors | Sui-Cheung Man, Ben H B Hung, Roger M K Ng, Xiao-Chun Yu, Hobby Cheung, Mandy P M Fung, Leonard S W Li, Kwok-Pui Leung, Kei-Pui Leung, Kevin W Y Tsang, Eric Ziea, Vivian T Wong, Zhang-Jin Zhang |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 14
Pg. 255
(Jul 19 2014)
ISSN: 1472-6882 [Electronic] England |
PMID | 25038733
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serotonin Uptake Inhibitors
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Topics |
- Aged
- Combined Modality Therapy
- Depression
(drug therapy, etiology, therapy)
- Electroacupuncture
(methods)
- Female
- Humans
- Male
- Middle Aged
- Pilot Projects
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Single-Blind Method
- Stroke
(psychology)
- Stroke Rehabilitation
- Treatment Outcome
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