Abstract |
The current study evaluated the anti- tumor activities of N-acetyl-d-glucosamine oligomer (NACOS) and glucosamine oligomer (COS) after their oral administration in a tumor (colon 26)-bearing mouse model. Compared to the control group, NACOS and COS groups showed significantly suppressed tumor growth, and apparent, marked apoptosis in tumor tissues. Furthermore, serum interleukin-12p70 and interferon-γ levels significantly increased in the NACOS and COS groups compared to the corresponding levels in the control group. Collectively, the results indicate the oral administration of NACOS and COS could enhance innate immunity. Results of experiments in Myd-88 knockout mice revealed that the apparent effects were related to both Myd-88-dependent and Myd-88-independent pathways. The data indicated that oral administration of NACOS and COS produced anti- tumor effects through the induction of apoptosis and stimulation of the immune system, which suggests that NACOS and COS are candidate anti- tumor functional foods.
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Authors | Sachie Masuda, Kazuo Azuma, Seiji Kurozumi, Masatoshi Kiyose, Tomohiro Osaki, Takeshi Tsuka, Norihiko Itoh, Tomohiro Imagawa, Saburo Minami, Kimihiko Sato, Yoshiharu Okamoto |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 111
Pg. 783-7
(Oct 13 2014)
ISSN: 1879-1344 [Electronic] England |
PMID | 25037416
(Publication Type: Journal Article)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Cytokines
- Interferon-gamma
- Glucosamine
- Acetylglucosamine
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Topics |
- Acetylglucosamine
(administration & dosage, therapeutic use)
- Administration, Oral
- Animals
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Apoptosis
(drug effects)
- Colon
(drug effects, pathology)
- Colonic Neoplasms
(blood, drug therapy, pathology)
- Cytokines
(blood)
- Disease Models, Animal
- Female
- Glucosamine
(administration & dosage, therapeutic use)
- Immunity, Innate
(drug effects)
- Interferon-gamma
(blood)
- Mice
- Mice, Inbred BALB C
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