Abstract | OBJECTIVES: METHODS: Patients with SLE in whom complement activation occurred were divided into two groups: those in whom the complement system was mainly activated through the classical pathway (low serum C3 and C4 levels; CP group); and those in whom the complement system was solely activated through the alternative pathway (low serum C3 with normal C4 levels; AP group). Clinical manifestations were compared between the groups. RESULTS: The CP group had higher frequencies of arthritis, serositis, and nephritis, and a higher prevalence of anti-DNA antibodies compared to the AP group ( arthritis: 50.0% vs. 13.0%, p = 0.0014; serositis: 37.5% vs. 13.0%, p = 0.0257; nephritis: 63.6% vs. 21.7%, p = 0.0003; anti-DNA antibodies: 73.9% vs. 30.4%, p = 0.0001). In contrast, the AP group had a higher frequency of anti- phospholipid (anti-PL) antibodies and a higher prevalence of antiphospholipid syndrome (APS) (anti-PL antibodies: 70.6% vs. 37.3%, p = 0.0136; APS: 39.1% vs. 5.7%, p < 0.0001). CONCLUSIONS: Our results suggest that a different complement system mechanism may act in the pathogenesis of APS in patients with SLE.
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Authors | Hiroshi Watanabe, Mitsuru Sugimoto, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Atsushi Takahashi, Kyoko Katakura, Hiroko Kobayashi, Hiromasa Ohira |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 25
Issue 2
Pg. 205-9
(Mar 2015)
ISSN: 1439-7609 [Electronic] England |
PMID | 25036235
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Antibodies, Antiphospholipid
- Complement C3
- Complement C4
|
Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Antiphospholipid
(blood)
- Antiphospholipid Syndrome
(blood, diagnosis, immunology)
- Complement Activation
(immunology)
- Complement C3
- Complement C4
- Female
- Humans
- Lupus Erythematosus, Systemic
(blood, diagnosis, immunology)
- Male
- Middle Aged
- Retrospective Studies
- Young Adult
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