Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.

Abstract

(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

• Authors: Y Fujita, T Yamane, M Tanaka, K Kuwata, J Okuzumi, T Takahashi, H Fujiki, T Okuda
• Journal: Japanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 80 Issue 6 Pg. 503-5 (Jun 1989) ISSN: 0910-5050 [Print] Japan
• PMID: 2503469 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carcinogens
• Methylnitronitrosoguanidine
• ENNG
• Catechin
• epigallocatechin gallate

Topics

• Animals
• Carcinogens
• Catechin (analogs & derivatives, therapeutic use)
• Duodenal Neoplasms (chemically induced, pathology, prevention & control)
• Male
• Methylnitronitrosoguanidine (analogs & derivatives)
• Mice
• Mice, Inbred C57BL
• Molecular Structure