[Preservative substances - the daily dose of benzalkonium chloride in glaucoma treatment from the patients point of view].

Abstract

The author calculated the daily dose of Benzalkonium Chloride (BAC) in eye drops used in glaucoma treatment from the patients point of view, which means the real amount of BAC applied in the conjunctival sac. The information about BAC concentration in 1 milliliter (mL) do not offer sufficient picture about real circumstances, because the size of the drop, especially after the introducing of the use of generic products in clinical practice in specific anti-glaucomatic drugs, differs significantly. The daily dose of BAC may have substantial significance in the patients treatment tolerance. The overview of BAC daily dose in single therapeutic groups and drugs follows: betablockers: Timo-COMOD 0, Arutimol 2.6, Vistagan 2.8, Timolol-POS 3.0, Arteoptic 3.7, Betoptic S 4.8, Timoptol MSD 6.3, Betoptic 10.0; alpha-mimetics: Alphagan 3.5, Luxfen 3.5, Aruclonin 7.1; derivates of prostaglandine, prostamides: Taflotan 0, Monopost 0, Lumigan 1.4, Unilat 3.1, Travatan 3.9, Latanoprost Apotex 4.3, Rescula 5.8, Latanoprost POS 5.9, Xalatan 6.0, Latanoprost Ratiopharm 6.0, Latanoprost Actavis 6.0, Latanoprost Arrow 6.0, Arulatan 5.4, Latalux 6.0, Glaucotens 6.0, Xaloptic 6.0, Solusin 6.1; carboanhydrase inhibitors: Batidor 3.8, Azopt 4.8, Trusopt 5.4, Oftidor 8.1; fixed combinations: Ganfort 1.4, Dorzolamid/timolol TEVA 2.8, Combigan 3.2, Duotrav 4.3, Cosopt 5.6, Xalacom 6.0, Glaucotima 6.0, Latanoprost/timolol Apotex 6.3, Azarga 6.4, Dorzogen Combi 6.5, and Dozotima 8.8 µl.

• Authors: P Výborný, S Sičáková, Z Veselá Flórová
• Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti (Cesk Slov Oftalmol) Vol. 70 Issue 3 Pg. 95-7 (Jun 2014) ISSN: 1211-9059 [Print] Czech Republic
• Vernacular Title: Konzervační činidla - denní dávka benzalkonium-chloridu v léčbě glaukomu z pohledu pacienta.
• PMID: 25032794 (Publication Type: Journal Article)

Chemical References

• Antihypertensive Agents
• Benzalkonium Compounds
• Ophthalmic Solutions
• Preservatives, Pharmaceutical

Topics

• Antihypertensive Agents (administration & dosage)
• Benzalkonium Compounds (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Compounding
• Glaucoma (drug therapy, physiopathology)
• Humans
• Intraocular Pressure (drug effects)
• Ophthalmic Solutions
• Preservatives, Pharmaceutical (administration & dosage)