Ubiquinol effect on sperm parameters in subfertile men who have astheno-teratozoospermia with normal sperm concentration.

Abstract

BACKGROUND:

Considering all the couples willing and trying to get pregnant, the incidence of infertility is 15% of which approximately half of the cases are due to the male factors.

OBJECTIVES:

The aim of this study was the investigation of the effects of ubiquinol, reduced form of coenzyme Q10 (Co-Q10), an empiric treatment modality, on sperm parameters in idiopathic subfertility.

PATIENTS AND METHODS:

In this retrospective study, 62 patients who had received 100 mg ubiquinol twice a day for six months due to idiopathic infertility since January 2012 to January 2013 were included. Only infertile patients with astheno-teratozoospermia without any identified etiology and with a spermatozoa concentration of greater than 13 × 10(6)/mL were included.

RESULTS:

The increase in mean values of concentration after the ubiquinol treatment was not statistically significant (P value = 0.065). However, the changes in morphology and motility (fast progressive [a] and a + slow progressive [b]) were statistically significant (P < 0.00).

CONCLUSIONS:

The weakness of the literature with regard to coenzyme Q10 is about its effects in patients with severely diminished sperm densities and the physiologic steps of morphologic improvements.

• Authors: Basri Cakiroglu, Seyit Erkan Eyyupoglu, Ramazan Gozukucuk, Bekir Sami Uyanik
• Journal: Nephro-urology monthly (Nephrourol Mon) Vol. 6 Issue 3 Pg. e16870 (May 2014) ISSN: 2251-7006 [Print] Netherlands
• PMID: 25032137 (Publication Type: Journal Article)