Abstract | BACKGROUND: OBJECTIVE: The objective was therefore to assess the effects of bolus administration of isomaltulose on glucose metabolism compared with sucrose in T2DM. DESIGN: In a randomized, double-blind, crossover design, 11 participants with T2DM initially underwent a 3-h euglycemic-hyperinsulinemic (0.8 mU · kg(-1) · min(-1)) clamp that was subsequently combined with 1 g/kg body wt of an oral (13)C-enriched isomaltulose or sucrose load. Hormonal responses and glucose kinetics were analyzed during a 4-h postprandial period. RESULTS: CONCLUSIONS: Ingestion of slowly absorbed isomaltulose attenuates postprandial hyperglycemia by reducing oral glucose appearance, inhibiting endogenous glucose production (EGP), and increasing SGU compared with ingestion of rapidly absorbed sucrose in patients with T2DM. In addition, GLP-1 secretion contributes to a beneficial shift in the insulin-to- glucagon ratio, suppression of EGP, and enhancement of SGU after isomaltulose consumption. This trial was registered at clinicaltrials.gov as NCT01070238.
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Authors | Meidjie Ang, Thomas Linn |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 100
Issue 4
Pg. 1059-68
(Oct 2014)
ISSN: 1938-3207 [Electronic] United States |
PMID | 25030779
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 American Society for Nutrition. |
Chemical References |
- Blood Glucose
- C-Peptide
- Dietary Carbohydrates
- Insulin
- Sucrose
- Gastric Inhibitory Polypeptide
- Isomaltose
- Glucagon-Like Peptide 1
- Glucagon
- isomaltulose
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Topics |
- Blood Glucose
(metabolism)
- C-Peptide
(blood)
- Carbohydrate Metabolism
- Cross-Over Studies
- Diabetes Mellitus, Type 2
(blood)
- Dietary Carbohydrates
(pharmacokinetics)
- Double-Blind Method
- Female
- Gastric Inhibitory Polypeptide
(blood)
- Glucagon
(blood)
- Glucagon-Like Peptide 1
(blood)
- Humans
- Hyperglycemia
(blood)
- Insulin
(blood)
- Isomaltose
(analogs & derivatives, pharmacokinetics)
- Male
- Middle Aged
- Postprandial Period
- Sucrose
(pharmacokinetics)
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