The purpose of this study was to evaluate the therapeutic efficacy of
pregabalin in patients with leg symptoms due to lumbar
spinal stenosis. Study subjects were classified into two groups according to their
pharmacotherapy: the
pregabalin group, treated with nonsteroidal anti-inflammatory
drug and
pregabalin combination
therapy, and the control group, treated with nonsteroidal anti-inflammatory
drug monotherapy. The two groups were compared in terms of the duration of
pain after the onset of leg symptoms and the type of neurogenic
intermittent claudication, whether radicular-, caudal-, or mixed-type. Numerical rating scale and Roland-Morris Disability Questionnaire scores were evaluated before and 3 months
after treatment. After 3 months of treatment, there were significant differences in the numerical rating scale for radicular- and mixed-types, but not for caudal-type, between the two groups in the subjects with leg symptoms for greater than 3 months. There were significant differences between the two groups in Roland-Morris Disability Questionnaire scores for mixed-type, but not for radicular- and caudal-types, in the subjects with leg symptoms for less than 3 months and for radicular- and mixed-types, but not for caudal-type, in the subjects with leg symptoms for greater than 3 months. Nonsteroidal anti-inflammatory
drug and
pregabalin combination
therapy may be more effective than nonsteroidal anti-inflammatory
drug monotherapy for the relief of leg symptoms due to lumbar
spinal stenosis, preventing aggravation of subjective symptoms and improving quality of life for patients with radicular- and mixed-types in subjects with leg symptoms for greater than 3 months, although it may be necessary to consider alternative
therapy for patients with caudal-type.