Abstract | BACKGROUND: METHODS: Male New Zealand white rabbits were treated with oral propranolol (0.25 mg/kg/6 h) for 5 d, and propranolol concentrations were measured after 1, 2, 3, and 6 h in plasma, aqueous humor, vitreous humor, and retina. These concentrations were compared with those obtained after the administration of one drop of 25 μl of propranolol 0.1% prepared in saline, applied every 6 h to both eyes for 5 d. A Draize eye test and histological analyses were performed to assess eye drop tolerability. RESULTS: The administration of eye drops produced retinal concentrations similar to, but plasma concentrations significantly lower than, those measured after oral administration. The local tolerability profile was excellent. CONCLUSION:
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Authors | Letizia Padrini, Benedetta Isacchi, Anna Rita Bilia, Alessandro Pini, Cecilia Lanzi, Emanuela Masini, Maria Luisa Della Bona, Anna Maria Calvani, Riccardo Ceccantini, Giancarlo la Marca, Luca Filippi |
Journal | Pediatric research
(Pediatr Res)
Vol. 76
Issue 4
Pg. 378-85
(Oct 2014)
ISSN: 1530-0447 [Electronic] United States |
PMID | 25029260
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Propranolol
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Topics |
- Administration, Ophthalmic
- Adrenergic beta-Antagonists
(administration & dosage, metabolism, pharmacokinetics)
- Animals
- Colony Count, Microbial
- Male
- Propranolol
(administration & dosage, adverse effects, pharmacokinetics)
- Rabbits
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