Risk factors associated with the development of hyperamylasemia and post-ERCP pancreatitis in the Cuban National Institute.

Abstract

CONTEXT:

Acute pancreatitis is the most common complication in ERCP, and some risk factors were associated with the development of hyperamylasemia and post-ERCP pancreatitis.

OBJECTIVES:

identifying new factors associated with the development of hyperamylasemia or post-ERCP pancreatitis in patients attended at our center.

MATERIAL AND METHODS:

A (retrospective) cohort study was carried out in 170 patients on which a diagnostic-therapeutic ERCP was done due to biliopancreatic disease. 67 patients developed hyperamylasemia (39.4%) and 6 post-ERCP pancreatitis (3.5%). The following diagnostic criteria were applied: Hyperamylasemia: increase in the serum amylase level above the normal value (90 I/U). Acute post-ERCP pancreatitis: clinical: continuous abdominal pain for over 24 hours and biochemical: elevation of amylase3 times above normal value (90 U/I).

RESULTS:

The number of cannulations more than 4 (19 patients), (p=0.006; RR= 3.00) was associated significantly with the development of hyperamylasemia and the placing of biliary stent (14 patients), (p=0.00; RR= 0.39) was a protective factor. The factors associated with the development of post-ERCP pancreatitis were related with the patient (peridiverticular location of the papilla (p=0.00; RR= 2.00) and the sphincter of Oddi dysfunction (p=0.000; RR=1.20).

CONCLUSION:

Technical factors were associated with the development of hyperamylasemia, however, the factors associated with the development of post-ERCP pancreatitis in our universe of study were related mainly with the patient.

• Authors: Héctor Ruben Hernández Garcés, Alonso Almeida Linnet, María del Rosario Abreu Vázquez, Luis Calzadilla Bertot, Kevin Peña, Yudit Andrain Sierra, Issoufo Moutary, Nilmer Segura Fernández
• Journal: Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru (Rev Gastroenterol Peru) Vol. 34 Issue 2 Pg. 127-32 (Apr 2014) ISSN: 1609-722X [Electronic] Peru
• PMID: 25028902 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Cholangiopancreatography, Endoscopic Retrograde (adverse effects)
• Cohort Studies
• Cuba
• Female
• Humans
• Hyperamylasemia (epidemiology, etiology)
• Male
• Middle Aged
• Pancreatitis (epidemiology, etiology)
• Retrospective Studies
• Risk Factors
• Young Adult