Abstract | BACKGROUND: METHODS: RESULTS: The expression levels of GSK-3α/β and pGSK-3α/β(Tyr279/216) in ovarian cancers were significantly higher than those in benign tumors. High expression of GSK-3α/β was more likely to be found in patients with advanced International Federation of Gynecology and Obstetrics (FIGO) stages and high serum cancer antigen 125. Higher expression of pGSK-3α/β(Tyr279/216) was associated with advanced FIGO stages, residual tumor mass, high serum cancer antigen 125, and poor chemoresponse. Worse overall survival was revealed by Kaplan-Meier survival curves in patients with high expression of GSK-3α/β or pGSK-3α/β(Tyr279/216). Multivariate analysis indicated that FIGO stage, GSK-3α/β expression, and pGSK-3α/β(Tyr279/216) expression were independent prognostic factors for overall survival. GSK-3 inhibition by lithium chloride, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8), or GSK-3 small interfering RNA can decrease viability of SKOV3 and SKOV3-TR30 ovarian cancer cells. Additionally, lithium chloride-treated SKOV3 xenograft mice had a significant reduction in tumor growth compared with control-treated animals. CONCLUSION:
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Authors | Yunfeng Fu, Xinyu Wang, Xiaodong Cheng, Feng Ye, Xing Xie, Weiguo Lu |
Journal | OncoTargets and therapy
(Onco Targets Ther)
Vol. 7
Pg. 1159-68
( 2014)
ISSN: 1178-6930 [Print] New Zealand |
PMID | 25028561
(Publication Type: Journal Article)
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