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Rilonacept for gout flare prevention in patients receiving uric acid-lowering therapy: results of RESURGE, a phase III, international safety study.

AbstractOBJECTIVE:
To evaluate the safety and efficacy of once-weekly subcutaneous rilonacept 160 mg for prevention of gout flares in patients initiating or continuing urate-lowering therapy (ULT).
METHODS:
This phase III study was conducted in the United States, South Africa, Europe, and Asia. Adults (n = 1315, 18-80 yrs) with gout, who were initiating or continuing ULT, were randomized to treatment with weekly subcutaneous injections of rilonacept 160 mg or placebo for 16 weeks followed by a 4-week safety followup. The primary endpoint was safety, assessed by adverse events (AE) and laboratory values. Efficacy was a secondary endpoint.
RESULTS:
Demographic and clinical characteristics were similar between treatments; predominantly male (87.8%), mean age 52.7 ± 11.3 years. Patients with ≥ 1 AE were 66.6% with rilonacept versus 59.1% placebo, with slightly more AE-related withdrawals with rilonacept (4.7% vs 3.0%) because of the greater incidence of injection site reactions (15.2% rilonacept, 3.3% placebo). Serious AE were similar in both groups, as were serious infections (0.9% placebo, 0.5% rilonacept); no tuberculosis or opportunistic infections occurred. Most common AE were headache, arthralgia, injection site erythema, accidental overdose, and pain in extremity. Of the 6 deaths, only 1 in the placebo group was considered treatment-related. At Week 16, rilonacept resulted in 70.3% fewer gout flares per patient (p < 0.0001), fewer patients with ≥ 1 and ≥ 2 gout flares (p < 0.0001), and 64.9% fewer gout flare days (p < 0.0001) relative to placebo.
CONCLUSION:
Weekly subcutaneous administration of rilonacept 160 mg showed no new safety signals. The safety profile was consistent with previous studies. Rilonacept also significantly reduced the risk of gout flares. Clinicaltrials.gov identifier NCT00856206; EudraCT No. 2008-007784-16.
AuthorsJohn S Sundy, H Ralph Schumacher, Alan Kivitz, Steven P Weinstein, Richard Wu, Shirletta King-Davis, Robert R Evans
JournalThe Journal of rheumatology (J Rheumatol) Vol. 41 Issue 8 Pg. 1703-11 (Aug 2014) ISSN: 0315-162X [Print] Canada
PMID25028379 (Publication Type: Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antirheumatic Agents
  • Gout Suppressants
  • Recombinant Fusion Proteins
  • Uric Acid
  • rilonacept
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antirheumatic Agents (administration & dosage, adverse effects, therapeutic use)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Gout (blood, drug therapy, prevention & control)
  • Gout Suppressants (therapeutic use)
  • Humans
  • Injections, Subcutaneous
  • Internationality
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Recombinant Fusion Proteins (administration & dosage, adverse effects, therapeutic use)
  • Treatment Outcome
  • Uric Acid (blood)
  • Young Adult

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