Abstract |
Interleukin 8 (IL-8) is used to evaluate the severity of inflammation in the airways. The aim of this study was to evaluate patients with chronic obstructive pulmonary disease ( COPD) for the presence of upper respiratory tract involvement by questioning patients regarding nasal symptoms and by measuring levels of IL-8 in nasal lavage material. A total of 47 COPD patients and 23 healthy controls were enrolled in this study. Pulmonary function tests were performed for all participants who were asked to complete a Sinonasal Outcome Test-20 (SNOT-20) questionnaire on the same day, as a measure of quality of life. Median IL-8 level in nasal lavage specimens of COPD patients with stable disease was higher than that of healthy controls. An increase in cigarette pack-years was significantly associated with an increase in nasal IL-8 levels. Similarly, IL-8 levels correlated positively with stage of COPD. A significant link between number of visits to the emergency department and stage of disease was observed. Patients with COPD had a significantly higher mean SNOT-20 severity score compared to healthy controls. Proper management of sinonasal disease may help to decrease the number of COPD attacks and consequently improve quality of life.
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Authors | Hacer Celik, Serdar Akpinar, Hayriye Karabulut, Pinar Oktar, Berna Dursun, Huyla Celenk Erguden, Sibel Gunay, Tugrul Sipit |
Journal | Inflammation
(Inflammation)
Vol. 38
Issue 2
Pg. 616-22
(Apr 2015)
ISSN: 1573-2576 [Electronic] United States |
PMID | 25028101
(Publication Type: Journal Article)
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Chemical References |
- CXCL8 protein, human
- Interleukin-8
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Inflammation
(immunology, pathology)
- Interleukin-8
(metabolism)
- Male
- Middle Aged
- Nasal Lavage
- Nasal Lavage Fluid
(chemistry)
- Pulmonary Disease, Chronic Obstructive
(pathology)
- Quality of Life
- Severity of Illness Index
- Smoking
(epidemiology)
- Surveys and Questionnaires
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