Abstract | AIM: METHODS: Three kinds of human pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and AsPC-1) were used in this study. Expression of H3 and H4 receptors in pancreatic cancer cells was identified with Western blotting. Effects of clobenpropit on cell proliferation, migration and apoptosis were evaluated. Alteration of epithelial and mesenchymal markers after administration of clobenpropit was analyzed. An in vivo study with a Panc-1 xenograft mouse model was also performed. RESULTS: CONCLUSION:
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Authors | Woo Hyun Paik, Ji Kon Ryu, Kyoung-Sin Jeong, Jin Myung Park, Byeong Jun Song, Sang Hyub Lee, Yong-Tae Kim, Yong Bum Yoon |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 20
Issue 26
Pg. 8545-57
(Jul 14 2014)
ISSN: 2219-2840 [Electronic] United States |
PMID | 25024609
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Biomarkers, Tumor
- HRH4 protein, human
- Histamine Agonists
- Histamine H3 Antagonists
- Imidazoles
- Receptors, G-Protein-Coupled
- Receptors, Histamine
- Receptors, Histamine H4
- Deoxycytidine
- Thiourea
- clobenpropit
- Gemcitabine
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Topics |
- Animals
- Antimetabolites, Antineoplastic
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(pharmacology)
- Apoptosis
(drug effects)
- Biomarkers, Tumor
(metabolism)
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Cell Proliferation
(drug effects)
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Epithelial-Mesenchymal Transition
(drug effects)
- Histamine Agonists
(administration & dosage)
- Histamine H3 Antagonists
(administration & dosage)
- Humans
- Imidazoles
(administration & dosage)
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Pancreatic Neoplasms
(drug therapy, metabolism, pathology)
- Receptors, G-Protein-Coupled
(agonists, metabolism)
- Receptors, Histamine
(metabolism)
- Receptors, Histamine H4
- Thiourea
(administration & dosage, analogs & derivatives)
- Tumor Burden
(drug effects)
- Xenograft Model Antitumor Assays
- Gemcitabine
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