Utility of the trough plasma imatinib level monitoring at two time points in patients with the chronic myeloid leukemia-chronic phase.

Abstract

INTRODUCTION:

Plasma imatinib levels vary widely in patients with the chronic myeloid leukemia-chronic phase, and studies have shown improved hematological, cytogenetic, and molecular responses in patients with the higher trough imatinib levels.

MATERIALS AND METHODS:

We analyzed 50 consecutive patients with the chronic myeloid leukemia-chronic phase and performed plasma imatinib levels at 1 month and 12 months and correlated them with complete hematological response at 3 months and molecular response at 12 months, respectively.

RESULTS:

Trough plasma imatinib levels at 1 month correlated well with complete hematological response at 3 months (P = 0.007) and levels at 12 months correlated with molecular response at 12 months (P = 0.04). Compliance to imatinib also significantly correlated with imatinib levels at 1 month (P = 0.0008) and imatinib levels at 12 months (P = 0.0002).

CONCLUSION:

Plasma imatinib levels may be of benefit in patients not achieving desired response at defined time intervals. The plasma level monitoring also helps in the assessment of drug compliance.

• Authors: Sanjeev Kumar Sharma, Suman Kumar, A R Vijayakumar, Tulika Seth, Pravas Mishra, Manoranjan Mahapatra, Sudha Sazawal, T Velpandian, Renu Saxena
• Journal: Journal of cancer research and therapeutics (J Cancer Res Ther) 2014 Apr-Jun Vol. 10 Issue 2 Pg. 305-8 ISSN: 1998-4138 [Electronic] India
• PMID: 25022382 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Pyrimidines
• Imatinib Mesylate

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Agents (pharmacokinetics, therapeutic use)
• Benzamides (pharmacokinetics, therapeutic use)
• Female
• Humans
• Imatinib Mesylate
• Leukemia, Myeloid, Chronic-Phase (blood, drug therapy)
• Male
• Medication Adherence
• Middle Aged
• Piperazines (pharmacokinetics, therapeutic use)
• Pyrimidines (pharmacokinetics, therapeutic use)
• Young Adult