In vitro diagnosis of immediate IgE-mediated drug hypersensitivity: warnings and (unmet) needs.

Abstract

Immediate drug hypersensitivity reactions (DHR) constitute an important health condition, with serious consequences of inadequate diagnosis. In this article, some of the most important issues related to in vitro diagnosis of IgE-mediated allergies are discussed. In vitro diagnostics will benefit from expanded and novel insights and understandings in drug chemical reactivity, protein binding, biotransformation, degradation, identification of (cross-reactive) drug antigenic determinants, and deeper understanding of sensitization routes. Collective efforts should be undertaken to activate fundamental and clinical investigations.

• Authors: Astrid P Uyttebroek, Vito Sabato, Chris H Bridts, Didier G Ebo
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 34 Issue 3 Pg. 681-9, x (Aug 2014) ISSN: 1557-8607 [Electronic] United States
• PMID: 25017685 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Immunoglobulin E

Topics

• Drug Hypersensitivity (blood, diagnosis, immunology)
• Humans
• Hypersensitivity, Immediate (blood, diagnosis, immunology)
• Immunoassay (methods)
• Immunoglobulin E (blood, immunology)