Abstract |
Microinjection of ibotenic acid into medial septum of rats decreased choline acetyltransferase (CAT) and high-affinity choline uptake (HACU) activities in hippocampus and retarded the learning of a spatial memory task in the radial-arm maze. Administration of MK-771, a stable TRH analog, to such animals restored HACU activity in hippocampus to normal levels. Daily treatment of rats with MK-771 prior to maze running also restored the animals' learning ability. MK-771 did not enhance hippocampal HACU activity or maze performance in sham-lesioned rats. These results suggest that MK-771 reversed the ibotenic acid-induced memory deficit by restoring septohippocampal cholinergic function. MK-771 and other TRH analogs may represent novel agents for improving memory deficits produced by cholinergic insufficiency in Alzheimer's disease.
|
Authors | A Horita, M A Carino, J Zabawska, H Lai |
Journal | Peptides
(Peptides)
1989 Jan-Feb
Vol. 10
Issue 1
Pg. 121-4
ISSN: 0196-9781 [Print] United States |
PMID | 2501767
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Antidepressive Agents
- Thiazolidines
- Ibotenic Acid
- Thyrotropin-Releasing Hormone
- pyro(l-alpha-aminoadipyl)-L-histidyl-L-thiazolidine-4-carboxamide
- Choline O-Acetyltransferase
|
Topics |
- Animals
- Antidepressive Agents
(pharmacology)
- Choline O-Acetyltransferase
(metabolism)
- Hippocampus
(drug effects, enzymology, physiology)
- Ibotenic Acid
(pharmacology)
- Learning
(drug effects)
- Male
- Rats
- Rats, Inbred Strains
- Reference Values
- Thiazolidines
- Thyrotropin-Releasing Hormone
(analogs & derivatives, pharmacology)
|