Abstract | BACKGROUND: OBJECTIVES: To determine tHcy standard values and the prevalence of hyperhomocysteinemia (HHC) and to examine their association with demographic and life style factors in the Greater Tunis population. METHODS: This cross-sectional study included 2712 subjects (1228 males and 1484 females) aged 35 - 70 years, living in the Greater Tunis region. tHcy was analyzed by a fluorescent polarizing immunoassay method. HHC was considered as tHcy > or = 15 micromol/L. RESULTS: HHC was observed in 23.7% of subjects. Plasma tHcy was higher in males than females (median (5th - 95th percentile): 13.5 [8.75 - 26.3] micromol/L vs. 10.7 [6.94 - 19.6] micromol/L). The tHcy concentration was significantly increased in smokers, alcoholics, in subjects with vitamin B12 and folate deficiencies, and hyperuricemia. In multivariate analysis, HHC was associated with male gender, vitamin B12 deficiency, clearance of creatinine, alcohol consumption, and hyperuricemia. CONCLUSIONS:
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Authors | Sameh Hadj-Taieb, Moncef Feki, Mohamed Bassem Hammami, Souheil Omar, Monia Elasmi, Amani Kallel, Haifa Sanhaji, Riadh Jemaa, Mohamed Hsairi, Naziha Kaabachi |
Journal | Clinical laboratory
(Clin Lab)
Vol. 60
Issue 6
Pg. 897-902
( 2014)
ISSN: 1433-6510 [Print] Germany |
PMID | 25016692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Analysis of Variance
- Cross-Sectional Studies
- Female
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(blood, epidemiology)
- Male
- Middle Aged
- Prevalence
- Reference Values
- Smoking
(blood)
- Tunisia
(epidemiology)
- Vitamin B 12 Deficiency
(blood)
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