The α1 adrenoceptor antagonist tamsulosin for the treatment of voiding symptoms improves nocturia and sleep quality in women.

Abstract

PURPOSE:

Nocturia is the main cause of disturbance of sleep maintenance and negatively impacts quality of life (QoL). We assessed the effects of the α1-adrenoceptor antagonist, tamsulosin, on nocturia and quality of sleep, for the treatment of lower urinary tract symptoms (LUTS) in women with a maximal flow rate (Qmax) less than 15 mL/sec.

MATERIALS AND METHODS:

From January 2008 to December 2009, women with LUTS [Qmax ≤ 15 mL/s, International Prostate Symptom Score (IPSS) ≥ 8] and nocturia (void/night ≥ 1) were selected for this study. Two hundred ninety six patients completed voiding diary, a questionnaire on the Medical Outcomes Study (MOS) sleep scale and underwent follow-up evaluation after 4 weeks of treatment (tamsulosin, 0.2 mg, once daily). Effectiveness was assessed by analysis of the IPSS, the bother score, the Qmax, and postvoid residual urine (PVR).

RESULTS:

The mean number of voids per night was 2.66 ± 1.3, and the total IPSS and bother scores were 15.2 ± 8.9 and 3.4 ± 1.2, respectively. Clinical parameters, including the IPSS, the bother score, the Qmax and the PVR, improved significantly from baseline after treatment (P < .05). The change in nocturia was -1.12 (P < .05). Concerning sleep quality, the sleep problem index showed a significant decrease. Among the items on the sleep subscale, sleep disturbance, somnolence, and sleep adequacy were significantly changed (P < .05).

CONCLUSION:

The α1-adrenoceptor antagonist tamsulosin significantly improved nocturia and sleep quality as well as LUTS in women with low Qmax.

• Authors: Sun-Ouck Kim, Hyang Sik Choi, Dongdeuk Kwon
• Journal: Urology journal (Urol J) Vol. 11 Issue 3 Pg. 1636-41 (Jul 08 2014) ISSN: 1735-546X [Electronic] Iran
• PMID: 25015610 (Publication Type: Journal Article, Observational Study)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Sulfonamides
• Tamsulosin

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Adult
• Aged
• Dyssomnias (etiology)
• Female
• Humans
• Lower Urinary Tract Symptoms (drug therapy)
• Middle Aged
• Nocturia (complications, drug therapy)
• Prospective Studies
• Quality of Life
• Severity of Illness Index
• Sleep
• Sulfonamides (therapeutic use)
• Surveys and Questionnaires
• Tamsulosin