Hsa-miR-1 downregulates long non-coding RNA urothelial cancer associated 1 in bladder cancer.
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| Abstract |
MicroRNAs (miRNAs) are known to mainly target protein-coding genes at post-transcriptional level, resulting in mRNA destabilization and/or translational repression. Long non-coding RNAs (lncRNAs) are emerging as a novel set of targets for miRNAs. Here, we report that downregulated hsa-miR-1 and upregulated lncRNA urothelial cancer associated 1 (UCA1) were inversely expressed in bladder cancer. Hsa-miR-1 decreased the expression of UCA1 in bladder cancer cells in an Ago2-slicer-dependent manner. The binding site between UCA1 and hsa-miR-1 was confirmed. Overexpression of hsa-miR-1 inhibited bladder cancer cell growth, induced apoptosis, and decreased cell motility. Knockdown of UCA1 expression phenocopied the effects of upregulation of hsa-miR-1. Transfection of UCA1 expression vector partly reversed the changes caused by transfection of pre-miR-1 plasmids. This study provides evidence for hsa-miR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer, which may have potential therapeutic significance.
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| Authors | Tiantian Wang, Jiancheng Yuan, Nenggui Feng, Yuchi Li, Zheguang Lin, Zhimao Jiang, Yaoting Gui |
| Journal | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 10 Pg. 10075-84 (Oct 2014) ISSN: 1423-0380 [Electronic] Netherlands |
| PMID | 25015192 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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