Evaluation of correlation of cell cycle proteins and Ki-67 interaction in paranasal sinus inverted papilloma prognosis and squamous cell carcinoma transformation.

Abstract

The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.

• Authors: Yung-An Tsou, Hung-Jin Huang, Tang-Chuan Wang, Chih-Jaan Tai, Chuan-Mu Chen, Calvin Yu-Chian Chen
• Journal: BioMed research international (Biomed Res Int) Vol. 2014 Pg. 634945 ( 2014) ISSN: 2314-6141 [Electronic] United States
• PMID: 25013792 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BPIFA1 protein, human
• Glycoproteins
• Ki-67 Antigen
• Phosphoproteins
• Proliferating Cell Nuclear Antigen
• TP53 protein, human
• Tumor Suppressor Protein p53
• p27 antigen
• CDC2 Protein Kinase
• CDK1 protein, human
• Cyclin-Dependent Kinases

Topics

• Adult
• Aged
• CDC2 Protein Kinase
• Carcinoma, Squamous Cell (genetics, pathology)
• Cell Transformation, Neoplastic (genetics, pathology)
• Cyclin-Dependent Kinases (biosynthesis)
• Female
• Gene Expression Regulation, Neoplastic
• Glycoproteins (biosynthesis)
• Humans
• Ki-67 Antigen (genetics)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (genetics, pathology)
• Papilloma, Inverted (genetics, pathology)
• Paranasal Sinus Neoplasms (genetics, pathology)
• Phosphoproteins (biosynthesis)
• Prognosis
• Proliferating Cell Nuclear Antigen (biosynthesis)
• Tumor Suppressor Protein p53 (biosynthesis)