Abstract | SUMMARY: Previous studies have not demonstrated a relationship between osteoporosis and cerebral infarction in the community, especially in men. We found that osteoporosis may be an independent risk factor for brain white matter change/silent infarction in men, as well as in women. PURPOSE: METHODS: This was a community-based, cross-sectional study supported by the regional government. Bone mineral density measurements and brain computed tomography were performed in 646 stroke- and dementia-free subjects (aged 50-75 years). RESULTS: After adjustment for age, hypertension, diabetes mellitus, dyslipidemia, and current smoking status, the odds ratio (OR) of risk for WMC and/or SI was 1.8 in the osteopenia group (95 % confidence interval [CI] 1.15-2.77; P = 0.01) and 2.2 in the osteoporosis group (95 % CI 1.42-3.55; P < 0.001). Among men, the OR was 1.8 (95 % CI 0.72-4.62; P = 0.21) and 3.8 (95 % CI 1.63-8.86; P = 0.002), and in women, the OR was 1.9 (95 % CI 1.15-2.78; P = 0.010) and 2.2 (95 % CI 1.42-3.55; P = 0.001), respectively. CONCLUSIONS: Severe bone mass loss may be an independent risk factor for brain WMC/SI in men and women. Low BMD may cause brain WMC/SI in the step that leads to stroke. Although there are well-designed studies on the prevention of cerebral infarction in patients with brain WMC/SI, a specific prevention method, such as aspirin, should be used for patients with low BMD who have WMC/SI. Screening for low BMD as an independent vascular risk factor in healthy subjects may be required to prevent stroke.
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Authors | Y K Minn, S H Suk, S Y Do |
Journal | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
(Osteoporos Int)
Vol. 25
Issue 10
Pg. 2465-9
(Oct 2014)
ISSN: 1433-2965 [Electronic] England |
PMID | 25011984
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Absorptiometry, Photon
(methods)
- Aged
- Bone Density
(physiology)
- Brain Infarction
(diagnostic imaging, epidemiology, etiology, physiopathology)
- Cross-Sectional Studies
- Female
- Humans
- Leukoencephalopathies
(diagnostic imaging, epidemiology, etiology, physiopathology)
- Male
- Middle Aged
- Osteoporosis
(complications, epidemiology, physiopathology)
- Republic of Korea
(epidemiology)
- Risk Factors
- Tomography, X-Ray Computed
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