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Endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer and dextranomer/hyaluronic acid in adults.

AbstractPURPOSE:
Aim of this study is to examine the effectiveness of dextranomer/hyaluronic acid copolymer and polyacrylate polyalcohol copolymer in endoscopic treatment of vesicoureteral reflux disease in adult patients with and without chronic renal failure.
MATERIALS AND METHODS:
Thirty two patients (12 female, 20 male) with a total of 50 renal units were treated for vesicoureteral reflux. There were 26 (81%) chronic renal failure patients. The success of treatment was evaluated by voiding cystouretrography at 3rd and 12th months after subureteric injection. The persistence of reflux was considered as failure. Patients were divided into two groups according to injected material. Age, sex, grade of reflux and treatment results were recorded and evaluated.
RESULTS:
Reflux was scored as grade 1 in seven (14%), grade 2 in 16 (32%), grade 3 in 21 (42%) and grade 4 in six (12%) renal units. There was not patient with grade 5 reflux. Fourteen renal units (28%) were treated with dextranomer/hyaluronic acid copolymer (group 1) and 36 renal units (72%) were treated with polyacrylate polyalcohol copolymer (group 2). The overall treatment success was achieved at 40 renal units (80%). The treatment was successful at 11 renal units (79%) in group 1 and 29 renal units (81%) in group 2 (p = 0.71). There was not statistically significant difference between two groups with patients with chronic renal failure in terms of treatment success (p = 1.00).
CONCLUSIONS:
The effectiveness of two bulking agents was similar in treatment of vesicoureteral reflux disease in adult patients and patients with chronic renal failure.
AuthorsAkif Turk, Ahmet Selimoglu, Kadir Demir, Osman Celik, Erkin Saglam, Fatih Tarhan
JournalInternational braz j urol : official journal of the Brazilian Society of Urology (Int Braz J Urol) 2014 May-Jun Vol. 40 Issue 3 Pg. 379-83 ISSN: 1677-6119 [Electronic] Brazil
PMID25010304 (Publication Type: Journal Article)
Chemical References
  • Acrylic Resins
  • Biocompatible Materials
  • Dextrans
  • dextranomer-hyaluronic acid copolymer
  • Hyaluronic Acid
Topics
  • Acrylic Resins (therapeutic use)
  • Adult
  • Biocompatible Materials (therapeutic use)
  • Dextrans (therapeutic use)
  • Female
  • Humans
  • Hyaluronic Acid (therapeutic use)
  • Injections (methods)
  • Kidney Failure, Chronic (physiopathology)
  • Male
  • Reproducibility of Results
  • Time Factors
  • Treatment Outcome
  • Ureteroscopy (methods)
  • Vesico-Ureteral Reflux (physiopathology, surgery)

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