Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat.

It has been suggested that a nonapeptide called V-9-M (Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met) is produced by the processing of procholecystokinin. However, its physiological and pharmacological activities are not known. In the present study, synthetic V-9-M amide was injected into the lateral ventricle of the rat and its effects on general activities were observed. V-9-M caused a marked sedation; it suppressed spontaneous activity and hypermotility induced by thyrotropin-releasing hormone, methamphetamine, and apomorphine. Hypomotility induced by small doses of apomorphine was also decreased further. V-9-M caused hypothermia and prolonged the duration of pentobarbital-induced sleep, and it decreased locomotion in an open-field situation. However, V-9-M did not affect appetite in fasted rats.
AuthorsA Takashima, S Itoh
JournalCanadian journal of physiology and pharmacology (Can J Physiol Pharmacol) Vol. 67 Issue 3 Pg. 223-7 (Mar 1989) ISSN: 0008-4212 [Print] CANADA
PMID2501013 (Publication Type: Journal Article)
Chemical References
  • Peptide Fragments
  • Protein Precursors
  • Methamphetamine
  • Thyrotropin-Releasing Hormone
  • procholecystokinin
  • Cholecystokinin
  • V-9-M cholecystokinin nonapeptide
  • Pentobarbital
  • Apomorphine
  • Animals
  • Apomorphine (pharmacology)
  • Behavior, Animal (drug effects)
  • Body Temperature (drug effects)
  • Cholecystokinin (administration & dosage, pharmacology)
  • Eating (drug effects)
  • Injections, Intraventricular
  • Male
  • Methamphetamine (pharmacology)
  • Motor Activity (drug effects)
  • Nervous System (drug effects)
  • Pentobarbital (pharmacology)
  • Peptide Fragments (administration & dosage, pharmacology)
  • Protein Precursors (administration & dosage, pharmacology)
  • Rats
  • Rats, Inbred Strains
  • Sleep (drug effects)
  • Thyrotropin-Releasing Hormone (pharmacology)

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