HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Comparison of ⁶⁸Ga-DOTATOC-PET/CT and PET/MRI hybrid systems in patients with cranial meningioma: Initial results.

AbstractBACKGROUND:
(68)Ga-DOTATOC-PET/CT is a well-established method for detecting and targeting the volume definition of meningiomas prior to radiotherapy. Moreover, there is evidence that this method is able to detect meningiomas with higher sensitivity than the goldstandard MRI. Since the hybrid PET/MRI scanner became available in the past few years, the next stage of development could consequently evolve by evaluating the feasibility of a hybrid PET/MRI scanner using (68)Ga-DOTATOC for detecting meningiomas.
METHODS:
Fifteen patients received (68)Ga-DOTATOC-PET/CT (0.5 h post injection [p.i.]) followed by PET/MRI 2 hours p.i. Both investigations were analyzed separately and then compared with respect to image quality, detection of intracranial meningiomas, and radiotracer uptake values (RUVs). In addition, ratios between radiotracer uptake in meningiomas and pituitary glands were compared between both PET/CT and PET/MRI.
RESULTS:
Overall, 33 intracranial meningiomas were detected. All were visible with high contrast in both PET/CT and PET/MRI. (68)Ga-DOTATOC-PET/MRI provided flawless image quality without artefacts. Calculated RUV in meningiomas, as well as the ratios of RUVs in meningiomas to those of pituitary glands, were higher in PET/CT. As a result, meningiomas can be distinguished from pituitary glands better in early images.
CONCLUSIONS:
(68)Ga-DOTATOC-PET/MRI provided flawless image quality and presented an ideal combination of high sensitivity/specificity (PET) and the best possible morphological visualization of meningiomas (MRI). In addition, excellent detection of meningiomas is already possible at 0.5 hours p.i. Later images do not improve the distinction between pituitary gland and adjacent meningiomas. However, RUVs need to be carefully compared between both imaging modalities.
AuthorsAli Afshar-Oromieh, Maya B Wolf, Clemens Kratochwil, Frederik L Giesel, Stephanie E Combs, Antonia Dimitrakopoulou-Strauss, Regula Gnirs, Matthias C Roethke, Heinz P Schlemmer, Uwe Haberkorn
JournalNeuro-oncology (Neuro Oncol) Vol. 17 Issue 2 Pg. 312-9 (Feb 2015) ISSN: 1523-5866 [Electronic] England
PMID25008094 (Publication Type: Journal Article)
Copyright© The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Chemical References
  • Contrast Media
  • Ga(III)-DOTATOC
  • Organometallic Compounds
  • Octreotide
Topics
  • Adult
  • Aged
  • Brain Neoplasms (diagnosis, radionuclide imaging)
  • Contrast Media
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging (methods)
  • Male
  • Meningeal Neoplasms (diagnosis, radionuclide imaging)
  • Middle Aged
  • Multimodal Imaging (methods)
  • Octreotide (analogs & derivatives)
  • Organometallic Compounds
  • Positron-Emission Tomography (methods)
  • Tomography, X-Ray Computed (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: