Abstract | BACKGROUND: MATERIAL AND METHODS: We enrolled 20 patients (18 men and 2 women, mean age 51 ± 12 years, diagnosed with congestive heart failure and pulmonary hypertension. This was a prospective, single-center study. Patients were treated with sildenafil 25 mg TDS for 12 months. Protocol included NYHA evaluation and repeated echocardiography, cardiac pulmonary stress tests, and right- sided catheterization. RESULTS: Initially, there were 16 (80%) patients in III NYHA status and 4 (20%) patients in II NYHA. After 12 months, 8 patients were in NYHA III (40%) status and 12 patients in NYHA II (60%). Peak oxygen consumption increased from 12 ± 3 ml/kg/min to 19 ± 4 ml/kg/min after 1-year therapy (p<0.001). The cardiac index increased from 3.1 ± 0.6 L/min/m2 to 3.6 ± 0.4 L/min/m2 (p<0.05). Pulmonary vasculature resistance decreased after 1-year therapy (4.7 ± 1 vs. 1.6 ± 0.5 Woods units (p<0.005) comparing to initials. Mean pulmonary artery pressure decreased to 23 ± 6 mmHg from 42 ± 5 mmHg (p<0.001) after 1-year therapy. CONCLUSIONS:
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Authors | Tomasz Urbanowicz, Ewa Straburzyńska-Migaj, Izabela Katyńska, Aleksander Araszkiewicz, Zofia Oko-Sarnowska, Stefan Grajek, Marek Jemielity |
Journal | Annals of transplantation
(Ann Transplant)
Vol. 19
Pg. 325-30
(Jul 09 2014)
ISSN: 2329-0358 [Electronic] United States |
PMID | 25007352
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Piperazines
- Purines
- Sulfones
- Vasodilator Agents
- Sildenafil Citrate
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Topics |
- Adult
- Cardiac Catheterization
- Exercise Test
(drug effects)
- Female
- Follow-Up Studies
- Heart Failure
(drug therapy)
- Humans
- Hypertension, Pulmonary
(drug therapy)
- Male
- Middle Aged
- Piperazines
(administration & dosage)
- Prognosis
- Prospective Studies
- Pulmonary Wedge Pressure
(drug effects)
- Purines
(administration & dosage)
- Severity of Illness Index
- Sildenafil Citrate
- Sulfones
(administration & dosage)
- Treatment Outcome
- Vascular Resistance
(drug effects)
- Vasodilator Agents
(administration & dosage)
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