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TFAA/H3PO4 mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells.

Abstract
For the first time TFAA/H3PO4 has facilitated the direct and metal-free N-acylation of carbazoles leading to a number of N-acylated derivatives. Several of these compounds were found to be promising when tested for their anti-proliferative properties against oral cancer cell lines.
AuthorsSunder Kumar Kolli, Bagineni Prasad, P Vijaya Babu, Mohd Ashraf Ashfaq, Nasreen Z Ehtesham, R Ramesh Raju, Manojit Pal
JournalOrganic & biomolecular chemistry (Org Biomol Chem) Vol. 12 Issue 32 Pg. 6080-4 (Aug 28 2014) ISSN: 1477-0539 [Electronic] England
PMID25006860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Acetic Anhydrides
  • Carbazoles
  • Carboxylic Acids
  • Fluoroacetates
  • Phosphoric Acids
  • Small Molecule Libraries
  • trifluoroacetic anhydride
  • phosphoric acid
Topics
  • Acetic Anhydrides (chemistry)
  • Acylation
  • Carbazoles (pharmacology)
  • Carboxylic Acids (chemistry)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Fluoroacetates (chemistry)
  • HEK293 Cells
  • Humans
  • Neoplasms (pathology)
  • Phosphoric Acids (chemistry)
  • Small Molecule Libraries (chemistry, pharmacology)
  • Stereoisomerism

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