[Health-related quality of life in children with epilepsy in a Mexican hospital].

Epilepsy is a chronic neurological syndrome that is accompanied by abnormal, synchronic and exaggerated discharges in the cerebral cortex. Epilepsy is inversely related to health-related quality of life (HRQL), although little has been published on this relationship in children in Latin America.
To examine the relation between epilepsy and HRQL in a group of schoolchildren aged 8-12 years who were treated in a paediatric hospital in Sonora, Mexico.
A cross-sectional study was conducted to compare the HRQL of children diagnosed with epilepsy with respect to the HRQL of two control groups. The validated questionnaire Paediatric Quality of Life Inventory was used to evaluate HRQL. Differences were examined by means of an ANOVA test and the association between epilepsy and HRQL was modelled by means of multiple logistic regression.
The children with epilepsy displayed the lowest HRQL score (62.4 ± 14.8) of the subjects studied and had 5.2 times as much risk of their HRQL deteriorating (95% confidence interval = 2.43-11.06) compared to healthy children. Deterioration was greater on the cognitive (54.6 ± 15.0) and emotional scales (55.9 ± 23.6). Polypharmacy, i.e. the concomitant ingestion of three or more drugs (p < 0.001), and the chronological progression of suffering (p < 0.001) are factors that significantly deteriorate the HRQL of children with epilepsy.
Epilepsy gives rise to an overall deterioration in the HRQL of children, specifically in the cognitive and emotional spheres, which is related with the chronological progression of the disease and polypharmacy.
AuthorsNed M Dávila-Ávila, Jesús Delgado-De la Mora, M Carmen Candia-Plata, Gerardo Alvarez-Hernández
JournalRevista de neurologia (Rev Neurol) Vol. 59 Issue 2 Pg. 63-70 (Jul 16 2014) ISSN: 1576-6578 [Electronic] Spain
Vernacular TitleCalidad de vida relacionada con la salud en niños con epilepsia de un hospital mexicano.
PMID25005317 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anticonvulsants
  • Affective Symptoms (etiology, psychology)
  • Anticonvulsants (adverse effects, therapeutic use)
  • Child
  • Cognition Disorders (etiology, psychology)
  • Cross-Sectional Studies
  • Disease Progression
  • Epilepsy (psychology)
  • Family Characteristics
  • Female
  • Hospitals, University (statistics & numerical data)
  • Humans
  • Interpersonal Relations
  • Male
  • Mexico
  • Polypharmacy
  • Quality of Life
  • Self Report
  • Socioeconomic Factors
  • Surveys and Questionnaires

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