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Punicalagin ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in mice.

Abstract
Punicalagin, a bioactive ellagitannin isolated from pomegranate, has been reported to have anti-inflammatory property. In the present study, we analyzed the role of punicalagin against acute respiratory distress syndrome (ARDS) induced by lipopolysaccharide (LPS) in mice. Male BALB/c mice with ARDS, induced by intranasal instillation of LPS, were treated with punicalagin 1 h prior to LPS exposure. The effects of punicalagin on pro-inflammatory cytokines, myeloperoxidase activity, nuclear factor kappa B (NF-κB) activation, and the histopathological changes were evaluated. The results showed that punicalagin treatment attenuated LPS-induced lung edema, elevating TNF-α, IL-6, and IL-1β levels in the bronchoalveolar lavage fluid (BALF). Meanwhile, punicalagin significantly inhibited LPS-induced increases in the macrophage and neutrophil infiltration of lung tissues and myeloperoxidase activity. Furthermore, punicalagin inhibits Toll-like receptor 4 (TLR4) expression and NF-κB activation induced by LPS. In conclusion, this is the first study to demonstrate that punicalagin protects against LPS-induced ARDS in mice. The underlying mechanisms may include inhibition of TLR4-mediated NF-κB signaling pathways.
AuthorsJingjing Peng, Dong Wei, Zengqiang Fu, Dong Li, Yong Tan, Tao Xu, Jinjun Zhou, Tao Zhang
JournalInflammation (Inflammation) Vol. 38 Issue 2 Pg. 493-9 (Apr 2015) ISSN: 1573-2576 [Electronic] United States
PMID25005005 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Hydrolyzable Tannins
  • IL1B protein, mouse
  • Interleukin-1beta
  • Interleukin-6
  • Lipopolysaccharides
  • NF-kappa B
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4
  • Tumor Necrosis Factor-alpha
  • punicalagin
  • Peroxidase
Topics
  • Acute Lung Injury (drug therapy)
  • Animals
  • Anti-Inflammatory Agents (therapeutic use)
  • Bronchoalveolar Lavage Fluid (chemistry, cytology)
  • Enzyme Activation (drug effects)
  • Hydrolyzable Tannins (therapeutic use)
  • Inflammation (drug therapy)
  • Interleukin-1beta (metabolism)
  • Interleukin-6 (metabolism)
  • Lipopolysaccharides
  • Lung (immunology, pathology)
  • Macrophages (immunology)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • NF-kappa B (metabolism)
  • Neutrophil Infiltration (drug effects, immunology)
  • Neutrophils (immunology)
  • Peroxidase (metabolism)
  • Pulmonary Edema (drug therapy)
  • Random Allocation
  • Respiratory Distress Syndrome (drug therapy)
  • Toll-Like Receptor 4 (biosynthesis)
  • Tumor Necrosis Factor-alpha (metabolism)

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