Abstract | BACKGROUND:
Myoglobin has become established as a serum marker of myocardial injury. However, myoglobin levels can increase exponentially without any correlation to postoperative clinical ischemia symptoms. In this retrospective study, we analyzed the associated factors for a non-ischemic myoglobin release. METHODS: RESULTS: Using a multifactorial model, predictive elements and associated factors for non-ischemic myoglobin increase were male sex, ejection fraction < 30%, BMI > 30 and transfusions. Serum myoglobin was not significantly different in patients with high muscle mass. CONCLUSIONS: A non-ischemic serum myoglobin release is rare, but could be associated in subgroups of patients. Further investigations should focus on clinical targets, for example, concomitant medications for which our study was not powered.
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Authors | Kiessling Arndt-H, Grohmann Florian, Stock Ulrich A, Beiras-Fernandez Andres, Kornberger Angela, Moritz Anton |
Journal | The heart surgery forum
(Heart Surg Forum)
Vol. 17
Issue 3
Pg. E163-8
(Jun 2014)
ISSN: 1522-6662 [Electronic] United States |
PMID | 25002394
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Biomarkers
(blood)
- Cardiopulmonary Bypass
(adverse effects, statistics & numerical data)
- Coronary Artery Bypass
(adverse effects, statistics & numerical data)
- False Positive Reactions
- Female
- Germany
(epidemiology)
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(blood, diagnosis, etiology)
- Myocardium
(metabolism)
- Myoglobin
(blood)
- Prevalence
- Reproducibility of Results
- Retrospective Studies
- Risk Factors
- Sensitivity and Specificity
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