Clinical association of circulating VEGF-B levels with hyperlipidemia and target organ damage in type 2 diabetic patients.

Abstract

Vascular endothelial growth factor-B (VEGF-B is an important member of the VEGF protein family. Recent animal studies indicated that VEGF-B signaling had determinant roles in insulin resistance, lipid distribution and metabolism in type 2 diabetes. The clinical significance of VEGF-B in type 2 diabetes is still not clear. This study aimed to correlate VEGF-B levels with biochemistry characteristics and target organ damage in type 2 diabetic patients. Serum VEGF-B levels were measured using ELISA. A crosssectional control study, which included 180 type 2 diabetic patients and 62 healthy subjects, was carried out. Diabetic patients who were undergoing insulin therapy were not included. This results showed that serum VEGF-B levels did not differ between the type 2 diabetic patients and the healthy controls (169.2∓118.8 vs 163.5∓115.2 pg/mL; P=0.734). VEGF-B levels in type 2 diabetic patients were significantly associated with the levels of c-peptide, total cholesterol and triglyceride. T-test analysis showed that the associations of serum VEGF-B levels with insulin resistance, pancreatic reserve, HDL and LDL were not significant. Regression analysis showed that VEGF-B levels were significantly correlated with diabetic retinopathy and nephropathy. No significant association between VEGF-B and macro-vasculopathy was found. In conclusion, our study findings suggested that VEGF-B levels did not differ between the type 2 diabetic patients and the normal controls. High VEGF-B levels might correlate with the presence of hyperlipidemia and target organ damage in type 2 diabetic patients.

• Authors: C Y Sun, C C Lee, M F Hsieh, C H Chen, K M Chou
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2014 Apr-Jun Vol. 28 Issue 2 Pg. 225-36 ISSN: 0393-974X [Print] Italy
• PMID: 25001655 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triglycerides
• VEGFB protein, human
• Vascular Endothelial Growth Factor B
• C-Reactive Protein
• Cholesterol

Topics

• Aged
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Cholesterol (blood)
• Cross-Sectional Studies
• Diabetes Complications (blood, pathology)
• Diabetes Mellitus, Type 2 (blood, pathology)
• Female
• Humans
• Hyperlipidemias (blood, pathology)
• Insulin Resistance
• Male
• Middle Aged
• Triglycerides (blood)
• Vascular Endothelial Growth Factor B (blood)